教育经历：
1. 2014.09-2017.06 中国农业科学院/上海兽医研究所，预防兽医学，博士。
2. 2010.09-2013.06 东北农业大学（哈尔滨兽医研究所联合培养），预防兽医学，硕士。
3. 2008.09-2010.06 青岛农业大学，动物医学，本科。
工作经历：
1. 2021.08-今天 山东第一医科大学（山东省医学科学院） 皇冠正规娱乐平台，副教授。
2. 2017.12-2021.06 广州医科大学附属第一医院/呼吸疾病国家重点实验，博士后。
3. 2013.08-2014.08 哈尔滨国生生物科技股份有限公司，病毒疫苗研发。
研究方向：病毒感染与宿主相互作用（呼吸道和肠道病毒）。
当前开展工作：冠状病毒天然免疫和手足口病mRNA疫苗。
科研业绩：
Ø 发表论文
第一/并列第一作者或通讯作者
1. Yuran Chen#, Wenjing Wang#, Wuchao Zhang#, Mei He, Yuming Li*, Guoshen Qu*, Jie Tong*, Emerging roles of biological m6A proteins in regulating virus infection: A review, Int J Biol Macromol, 2023.9.16, 253(Pt 3):126934(一区，IF=8.2)
2. Yuming Li#, Yingkang Jin#, Lijun Kuang#, Zhenhua Luo#, Fang Li, Jing Sun, Airu Zhu1, Zhen Zhuang, Yanqun Wang, Liyan Wen, Donglan Liu, Chunke Chen, Mian Gan, Jingxian Zhao*, Jincun Zhao*. The N-terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein ORF8b is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus, Journal of Virology, 2021 Nov 24; JVI0184221. Article.（二区，IF=5.1）
3. Yuming Li#, Guixue Hou#, Haibo Zhou#, Yanqun Wang#, Hein Min Tun#, Airu Zhu, Jingxian Zhao, Fei Xiao, Shanwen Lin, Dongdong Liu, Dunrong Zhou, Lang Mai, Lu Zhang, Zhaoyong Zhang, Lijun Kuang, Jiao Guan, Qiushi Chen, Liyan Wen, Yanjun Zhang, Jianfen Zhuo, Fang Li, Zhen Zhuang, Zhao Chen, Ling Luo, Donglan Liu, Chunke Chen, Mian Gan, Nanshan Zhong, Jincun Zhao*, Yan Ren*, Yonghao Xu*. Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis, prognosis and drug target discovery. Signal Transduct Target Ther. 6, 155 (2021). Article.（一区，IF=18.1）
4. Zhen Zhuang#, Xiaomin Lai#, Jing Sun#, Zhao Chen#, Zhaoyong Zhang#, Jun Dai#, Donglan Liu#, Yuming Li#, Fang Li#, Yanqun Wang, Airu Zhu, Junxiang Wang, Wenhui Yang, Jicheng Huang, Xiaobo Li, Lingfei Hu, Liyan Wen, Jianfen Zhuo, Yanjun Zhang, Dingbin Chen, Suxiang Li, Shuxiang Huang, Yongxia Shi, Kui Zheng, Nanshan Zhong, Jingxian Zhao*, Dongsheng Zhou*, Jincun Zhao*, Mapping and Role of T Cell Response in SARS-CoV-2 infected Mice, J Exp Med, 2021 Apr 5;218(4). Article.（一区，IF=14.3）
5. Hongliang Zhang#, Yuming Li#, Jing Sun#, Yuyuan Zhang#, Tongyun Wang, Mingxia Sun, Menghang Wang, Yuelin Yang, Xiaoliang Hu, Yandong Tang*, Jincun Zhao*, Xuehui Cai*. Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species. J Biol Chem, 2021 Feb 18;100435. Article.（二区，IF=5.1）
6. Li Yuming, Wu Zhuanchang, Liu Ke, Qi Pengfei, Xu Jinpeng, Wei Jianchao, Li Beibei, Shao Donghua, Shi Yuanyuan, Qiu Yafeng*, Ma Zhiyong*. Doxycycline enhances adsorption and inhibits early-stage replication of porcine reproductive and respiratory syndrome virus in vitro. FEMS microbiology letters 364, doi:10.1093/femsle/fnx170 (2017). Article. (四区，IF=2.7)
7. Yuming Li, Ke Liu, Zhuanchang Wu, Pengfei Qi, Jianchao Wei, Beibei Li, Donghua Shao, Yuanyuan Shi, Yafeng Qiu* and Zhiyong Ma* Proteomic Analysis of the Secretome of Porcine Alveolar Macrophages Infected with Porcine Reproductive and Respiratory Syndrome Virus. Proteomics 17, doi:10.1002/pmic.201700080 (2017).（三区，IF=3.9）
8. Yuming Li#, Gang Wang#, Yonggang Liu, Yuli He, Zhiyan Wang, Zifeng Han, Li Li, Aidong Li, Ye Tao, Xuehui Cai*. Identification of apoptotic cells in the thymus of piglets infected with highly pathogenic porcine reproductive and respiratory syndrome virus. Virus research 189, 29-33. doi:10.1016/j.virusres.2014.04.011. Article.（四区，IF=3.3）
9. 李玉明，王刚，汪志艳，刘永刚，涂亚斌，王淑杰，姜成刚，王延群，蔡雪辉*. 猪 凋亡相关基因 SYBR GreenⅠ荧光定量 RT-PCR 方法的建立. 中国预防兽医学报，2013.5, 中文核心期刊。
10. 李玉明，武专昌，刘珂，马改妮，魏建超，邵东华，李蓓蓓，邱亚峰，石元元，马志永*。PRRSV 感染对猪肺泡巨噬细胞 IFITM3 基因转录的影响。中国动物传染病学报，2017.4, 中文核心期刊。
参与发表论文
1. Zhuanchang Wu # , Zhaoying Zhang #, Xin Wang #, Jing Zhang #, Caiyue Ren, Yuming Li, Lifen Gao, Xiaohong Liang, Peihui Wang*, Chunhong Ma*, Palmitoylation of SARS-CoV-2 S protein is essential for viral infectivity. Signal Transduct Target Ther, 2021. 6(1): p. 231(IF=18.1)
2. Xin Wang#, Zhuanchang Wu#, Yuming Li, Yifan Yang, Changguang Xiao, Xiqian Liu, Xiao Xiang, Jianchao Wei, Donghua Shao, Ke Liu, Xufang Deng, Jiaqiang Wu, Yafeng Qiu, Beibei Li*, Zhiyong Ma*. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. PLoS Pathog 16 (10):e1009035, doi 10.1371/journal.ppat.1009035. (IF=6.8).
3. Wang Y#, Zhang L#, Sang L#, Ye F#, Ruan S#, Zhong B#, Song T#, Alshukairi AN#, Chen R, Zhang Z, Gan M, Zhu A, Huang Y, Luo L, Mok CK, Al Gethamy MM, Tan H, Li Z, Huang X, Li F, Sun J, Zhang Y, Wen L, Li Y, Chen Z, Zhuang Z, Zhuo J, Chen C, Kuang L, Wang J, Lv H, Jiang Y, Li M, Lin Y, Deng Y, Tang L, Liang J, Huang J, Perlman S, Zhong N, Zhao J*, Malik Peiris JS*, Li Y*, Zhao J*. 2020. Kinetics of viral load and antibody response in relation to COVID-19 severity. J Clin Invest doi:10.1172/jci138759.(IF=14.8)
4. Sun J*, Zhu A*, Li H*, Zheng K*, Zhuang Z*, Chen Z*, Shi Y*, Zhang Z*, Chen SB*, Liu X*, Dai J, Li X, Huang S, Huang X, Luo L, Wen L, Zhuo J, Li Y, Wang Y, Zhang L, Zhang Y, Li F, Feng L, Chen X, Zhong N, Yang Z*, Huang J*, Zhao J*, Li YM*. 2020. Isolation of infectious SARS-CoV-2 from urine of a COVID-19 patient. Emerg Microbes Infect 9:991-993.(IF=5.77).
5. Butler JE*, Sinkora M, Wang G, Stepanova K, Li Y, Cai X. 2019. Perturbation of Thymocyte Development Underlies the PRRS Pandemic: A Testable Hypothesis. Front Immunol 10:1077.(IF=5.08)
6. Pengfei Qi#, Ke Liu#, Jianchao Wei, Yuming Li, Beibei Li, Donghua Shao, Zhuanchang Wu, Yuanyuan Shi, Guangzhi Tong, Yafeng Qiu* and Zhiyong Ma*. Nonstructural Protein 4 of Porcine Reproductive and Respiratory Syndrome Virus Modulates Cell Surface Swine Leukocyte Antigen Class I Expression by Downregulating β2-Microglobulin Transcription. JVI，2017.02.(IF=5.1)
7. Gang Wang#, Li Li# , Ying Yu , Yabin Tu , Jie Tong , Chong Zhang, Yonggang Liu, Yuming Li, Zifeng Han, Chenggang Jiang, Shujie Wang, En-Min Zhou, Xijun He*, Xuehui Cai*. Highly pathogenic porcine reproductive and respiratory syndrome virus infection and induction of apoptosis in bone marrow cells of infected piglets. J Gen Virol. 2016.06.(IF =3.8)
8. Z. Han, Y. Liu, G. Wang, Y. He, S. Hu, Y. Li, W. Shi, J. Wu, S. Wang, H. Liu, X. Cai*. Comparative Analysis of Immune Responses in Pigs to High and Low Pathogenic Porcine Reproductive and Respiratory Syndrome Viruses Isolated in China, Transboundary And Emerging Diseases.2015.12.（IF=5.0）
9. Zhuan chang# Wu, Xin# Wang, Jian chao Wei, Bei bei Li, Dong hua Shao, Yu ming Li, Ke Liu, Yuan yuan Shi, Bin Zhou, Ya feng Qiu and Zhi yong Ma,∗ Antiviral activity of doxycycline against vesicular stomatitis virus in vitro. FEMS Microbiology Letters. 2015.10. （IF=2.7）
10. Gang Wang#, Ying Yu#, Yabin Tu, Yuming Li, Jie Tong, Chong Zhang, Yonggang Liu, Aidong Li, Chenggang Jiang, Shujie Wang, Ye Tao, Xuehui Cai*. Characterizing the thymic lesions in piglets infected with attenuated strains of highly pathogenic porcine reproductive and respiratory syndrome virus. Veterinary Immunology and Immunopathology. 2015.12.（IF=2.0）
11. Ke Liu, Yuming Li, Bin Zhou, Feifei Wang, Beili Huan, Donghua Shao, Jianchao Wei, Yafeng Qiu, Beibei Li, Yingjuan Qian, Yong-Sam Jung, Denian Miao, Guangzhi Tong, Zhiyong Ma*. A conjugate protein containing HIV TAT, ISG20, and a PRRSV polymerase binding inhibits PRRSV replication and may be a novel therapeutic platform. Res Vet Sci. 2017.08.（IF=2.5）
Ø 科研项目
主持项目
1. 中东呼吸综合征冠状病毒附属蛋白ORF4a增强病毒毒力机制研究，国家自然科学基金青年项目，主持，2021.01-2023.12，24万，在研。
2. 中东呼吸综合征冠状病毒附属蛋白对病毒毒力的影响，第63批中国博士后基金一等资助，主持，2018.01-2019.12，8万，结题。
3. 中东呼吸综合征冠状病毒附属蛋白ORF8b增强病毒毒力机制研究，呼吸疾病国家重点实验室自主课题项目，主持，2019.01-2021.12，20万，结题。
参与项目
1. Spike蛋白棕榈酰化修饰调控SARS-CoV-2病毒感染的作用及分子机制，国家自然科学基金面上项目，2022.01-2025.12，参与，58万，在研。
2. 探索不同人冠状病毒之间的交叉免疫保护作用，国家自然科学基金委员会, 国际(地区)合作与交流项目, 2019.01-2022.12，参与，100万，在研。
3. 新型冠状病毒2019-nCoV致病机制研究，广东省科学技术厅，科技攻关专项，2020.01-2021.01，参与，100万，结题。
奖项
2021年度广州市医学会医学优秀学术论文一等奖
